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65
66All data is available under the Open Government Licence v3.0 unless otherwise stated.
67
68
69
70
71from random import choice, choices
72
73nucleobase = "AGCT"
74
75start_codon = "ATG"
76stop_codon = ("TAG", "TAA", "TGA")
77
78def isPotentialGene(DNA: str):
79    # длина кратна 3
80    if (len(DNA) % 3) != 0:
81        return False
82    # начинается с кодона начала
83    if not DNA.startswith(start_codon):
84        return False
85    # не имеет кодонов конца внутри
86    for i in range(len(DNA) - 3):
87        if i % 3 == 0:
88            if DNA[i:i+3] in stop_codon:
89                return False
90    # завершается кодоном конца
91    if DNA.endswith(stop_codon[0]):
92        return True
93    if DNA.endswith(stop_codon[1]):
94        return True
95    if DNA.endswith(stop_codon[2]):
96        return True
97    return False
98
99
100# 0
101def generateCodon(triplets: int):
102    if triplets <= 0:
103        raise ValueError("the minimum number of triplets is 1")
104    codons = ""
105    while triplets > 0:
106        if (codon := "".join(choices(nucleobase, k=3))) not in stop_codon:
107            codons += codon
108            triplets -= 1
109    return codons
110
111def generateDNA(length: int):
112    if length <= 6 or length % 3 != 0:
113        raise ValueError("the length of the DNA must be greater than six and a multiple of six")
114    return start_codon + generateCodon(int((length - 6) / 3)) + choice(stop_codon)
115
116# 1
117def isValidDNA(st: str):
118    return set(st).issubset(nucleobase)
119
120# 2
121def complementWC(DNA: str):
122    return ''.join([{'A': 'T', 'T': 'A', 'C': 'G', 'G': 'C'}[base] for base in DNA])
123
124# 3
125def palindromeWC(DNA: str):
126    return DNA == complementWC(DNA)[::-1]
127
128# 4
129def isShift(s: str, t: str):
130    return len(s) == len(t) and t in s + s
131
132# 5
133def find_PotentialGene(DNA: str, length: int):
134    potential_genes = []
135    for i in range(len(DNA)):
136        if DNA[i:i+3] == start_codon:
137            for j in range(i+3, len(DNA), 3):
138                if DNA[j:j+3] in stop_codon:
139                    gene = DNA[i:j+3]
140                    if len(gene) >= length and len(gene) % 3 == 0:
141                        potential_genes.append(gene)
142                    break
143    if not potential_genes:
144        return None
145    return potential_genes
146
147# 6
148def caesar_cipher(text: str, ROT: int, decipher=False):
149    if ROT < 0:
150        raise ValueError("the number of shifts must be greater than or equal to zero")
151    encrypted_text = ""
152    if decipher:
153        ROT = -ROT
154    for char in text:
155        if char.isalpha():
156            shifted = ord(char) + ROT
157            if char.islower():
158                if shifted > ord("z"):
159                    shifted -= 26
160                elif shifted < ord("a"):
161                    shifted += 26
162            elif char.isupper():
163                if shifted > ord("Z"):
164                    shifted -= 26
165                elif shifted < ord("A"):
166                    shifted += 26
167            encrypted_text += chr(shifted)
168        else:
169            encrypted_text += char
170    if not encrypted_text:
171        return None
172    return encrypted_text